Association study on polymorphisms of α-synuclein gene in rs356219, rs356165 sites with cognitive dysfunction in Parkinson disease

Objective To investigate the relationship between two single nucleotide polymorphisms (rs356219, rs356165 sites) and cognitive dysfunction in Parkinson disease. Methods 236 patients with Parkinson's disease were randomly selected from November 2014 to November 2017. According to the results of MoCA cognitive function evaluation, the patients were divided into group A (cognitive dysfunction group) and group B (normal cognition group). At the same time, 65 patients were randomly selected as group C(Health control group). The allele frequency and genotype distribution of rs356219 and rs356165 were compared, and the differences among the three group were compared. Results In the rs356165 allele frequency, group A (G: 57.14%, A: 42.86%), group B (G: 56.45%, A: 43.55%) and group C (G: 52.31%, A: 47.69%) had no statistical significance (P>0.05). In the rs356165 genotype, G/G (21.43%) and A/A (14.29%) in group A were higher than group C (G/G: 4.62%, A/A: 1.54%), G/G (22.58%) in group B and A/A (14.52%) were higher than group C G/G(4.62%) and A/A(1.54%) (P 0.05); In the rs356219 genotype, group A (G/G: 35.71%, A/A: 21.43%, A/G: 42.86%), group B (G/G: 35.48%, A/A: 22.58%, A/G: 41.94%) and group C (G/G: 30.77%, A/A: 26.15%, A/G: 43.08%) had no statistical significance (P>0.05), and there was no statistical significance between group A and group B (P>0.05). Conclusions The polymorphism of rs356219 and rs356165 sites in rho-synaptic nucleoprotein plays an important role in the pathogenesis of Parkinson disease.However, there was no correlation with cognitive dysfunction in patients with Parkinson disease. Key words: Parkinson disease; Alpha-synapse nuclear protein; rs356219; rs356165; Cognitive dysfunction