Effect of alprostadil on early proinflammatory cytokines and its therapeutic effect in patients with severe acute pancreatitis

Objective 　To investigate the effects of alprostadil on expression of proinflammatory cytokines in patients with severe acute pancreatitis (SAP) and evaluate the clinical efficacy. Methods 　Seventy-three SAP patients were collected from January 2014 to May 2016, and then were randomly divided into control group (n=37) and experimental group (n=36). On the basis of routine treatment, the experimental group patient was given alprostadil at a dose of 15µg/d. The expression of C-reactive protein (CRP), white blood cell (WBC) count, amylase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, serum proinflammatory cytokine tumor necrosis factor alpha (TNF-α), interleukin -1 beta (IL-1β), interleukin -6 (IL-6) were detected in serum on the 1st, 3rd and 7th day. Results 　The biochemical indexes and expression of proinflammatory cytokines were significantly increased in the two groups on the 1st day, and decreased gradually, with a significant difference between the time points (P 0.05). These indexes were decreased significantly with the passage of time and there were significant differences between the two groups at the 3rd and 7th day (P<0.05). Conclusion 　Alprostadil can effectively reduce the severity of early inflammatory reaction in SAP patients, and has important significance for improving the prognosis. DOI: 10.11855/j.issn.0577-7402.2017.02.09