INFLUENTA SI PREVALENTA STEATOZEI HEPATICE NON-ALCOOLICE ÎN HEPATITA CRONICÃ VHB

The prevalence and the impact of nonalcoholic fattyliver disease (NAFLD) on chronic hepatitis B (CHB) are not well known. NAFLD as thehepatic manifestation of the metabolic syndrome (MS) is associated with obesity, diabetesmellitus and dislipidemia. Aim: To evaluate the prevalence and the impact of NAFLD onCHB. Methods: 120 patients diagnosed serologically and histological with CHB in 2006 inour center were retrospectively analyzed. Patients with self declared excessive alcohol consumption(above 20g/day for males and 10g/day for females) have been excluded. NAFLD wasevaluated according to Brunt’s score, while histology activity index (HAI) and fibrosis stagefor CHB were estimated using Knodell score. The patients were divided in 2 groups: patientswith CHB without steatosis (n=61) and with steatosis (n=59). Results: Out of 120 patientswith CHB (male/female=76/44, median age=40.41), 49.15% had steatosis. No statisticallysignificant differences among fibrosis stages, HAI and the aminotransferase levels was foundbetween the two groups (p=0.320, p=0.228, and p=0.128). The presence of NAFLD associatedwith CHB was significantly correlated with age (p=0.001) and MS (p=0.051). Inpatients with CHB and steatosis, significant correlations between female sex and the presenceof MS (p=0.007) as between HAI and age (p=0.003) were found. Conclusions: NAFLD wasdetected at 49.16% of patients with CHB. A positive correlation with age and MS (obesity,diabetes mellitus and/or dislipidemia) was observed. No significant correlations betweenNAFLD and the aminotransferase levels or histological features have been found.