Hyperglycemia-induced S100A8 and S100A9 expression target Akt, mTOR and NF-kB signalling in pancreatic cancer cells

s / Pancreatology 12 (2012) 502–597 505 Results: During the course of the study, the average level of IL-6 was significantly (p<0.05) higher in SAAP than in MAAP. Serum levels of IL-8 and IL-12p40 on admission were higher in SAAP than with MAAP but the difference was not statistically significant. Of all the types of WBCs, only neutrophils were significantly (p<0.05) elevated the entire time in SAAP patients when compared to MAAP. Conclusion: Patients with SAAP had significantly higher IL-6 levels and neutrophil counts than patients with MAAP. The results suggest that proliferation and overstimulation of this subset of leukocytes might contribute to the development of the systemic inflammatory response in patients with SAAP.