Equimolar doses of mannitol and hypertonic saline in the treatment of increased intracranial pressure.

Objective:To compare the effects of equimolar doses of 20% mannitol solution and of 7.45% hypertonic saline solution (HSS) in the treatment of patients with sustained elevated intracranial pressure (ICP).Design:Parallel, randomized, controlled trial.Setting:Two intensive care units in a university h