Outcomes of blood purification on clearance of serum advanced glycation end products and beta 2-microglobulin

Objective To compare the clearance efficacy of purification medhods on serum advanced glycation end products(AGEs)and beta2-microglobulin(β2-MG).Methods Forty-eight patients on maintenance hemodialysis were divided randomly into three groups of hemodialysis(group HD),hemodiafiltration(group HDF) and hemoperfusion plus hemodialysis(group HP+HD) with 16 cases each.Serum AGEs and β2-MG were measured before and after single blood purification.The efficacy of clearance was analysed.Results Serum levels of AGEs and β2-MG were lower after blood purification than those before in groups of HDF and HP+HD(P 0.05),which were lower in groups of HDF and HP+HD than those in group HD(P 0.05).Conclution The methods of blood purification in uremia patients are the main factors for reducing serum AGEs and β2-MG,of which HDF or HP+HD is better than HD.