AB0422 Mental disorders and stress in sjögren’s syndrome patients

Background The primary Sjogren’s Syndrome (SS) - a chronic, systemic autoimmune disease, characterized by lymphocytic infiltration of endocrine glands, functional impairment of the salivary and lachrymal glands, which has some common pathogenic links with stress-related mental disorders (MD). The physical and mental well being of the patients with primary SS are significantly reduced. The patients with SS have significantly high scoring rates for anxiety, depression, paranoid ideation and somatization compared to the controls. Objectives To evaluate the occurrence rate/severity of MD and the influence of stress factors in SS patients. Methods 50 inpatient women (mean age 46±13.2 yrs) suffering SS were enrolled in the study. MD were diagnosed in accordance with ICD-10 criteria. The severity of depression, anxiety, stress and fatigue were measured with MADRS, HAM-A, PSS-10 and FSS. Results The acute stress factors and reactions were preceded the SS symptoms in most cases (54%). The variants of stress factors revealed: “danger” (40%), “loss” (38%), “frustration” (16%) and “disaster” (6%). In most cases “loss”, “frustration”, “disaster” were related to acute and “danger” - chronic reactions (p Conclusions The study revealed high occurrence rate of MD, provocative stress factors and childhood adverse experience in SS patients. The results support the stress-diathesis model of mental disorders in patients suffering SS. Disclosure of Interest None Declared