NATRIURETIC PEPTIDES AS PREDICTIVE BIOMARKERS OF TREATMENT RESPONSE IN CLINICAL TRIALS OF HEART FAILURE

The lack of reliable predictors of efficacy of HF drugs and devices has presented a major hurdle to the evaluation of novel therapies. We explore whether short-term treatment-related changes in natriuretic peptides (NP) predict long-term therapeutic effects using a) patient-level data from PARADIGM