Role of calorie restriction on pathophysiological changes in tongue fat and its relation to increased risk factors of obstructive sleep apnea in WNIN/Ob obese rats

Purpose Obstructive sleep apnea is an outcome of obesity, resulting from abnormal upper airway structures. Our main objective was to assess the fat infiltration into the tongue of calorie-restricted rats and its consequences on upper airway obstruction in comparison with lean and obese rats.