Letrozole as a booster therapy in growth hormone deficiency.

625 VOLUME 46__JULY 17, 2009 Estrogen is an essential regulator of bone maturation, growth plate fusion, and cessation of longitudinal growth(1). Therefore, an increase in adult height may be achieved in short children by blocking estrogen biosynthesis. Aromatase is the key enzyme for estrogen biosynthesis and aromatase inhibitors (AI) have been used primarily in women with breast carcinoma. The use of aromatase inhibitors may provide a means to delay skeletal maturation and increase final height in children with short stature(2).