P256 - Epidemiology of inflammatory bowel diseases in northwestern Greece for the years 1981–2007

factors that could have influence on development of these symptoms. Methods: We performed a study in which we only included CD patients older than 18 years with at least 6 months in remission. CD remission was defined by a Crohn’s disease Activity Index (CDAI) <150 points together with a C-reactive protein <5mg/l. A demographic questionnaire that included age, gender, level of studies, marital status and smoking habits was performed. All patients were clinical stratified by years of disease, location and behaviour of the disease according to the Montreal Classification, perianal disease, extraintestinal manifestations, previous bowel resection and if had previously developed steroid-dependency or steroidresistance. The different treatments which patients maintained remission was also evaluated. Hospital Anxiety and Depression scale (HAD) was performed in all patients. Results are shown in percentages and analyzed by logistic regression, results of p < 0.05 were considered as statically significant. Results: 92 consecutive patients were included; (48 male and 44 female), mean age 37 years, range from 18 to 71). 1 (1%) patient failed to respond correctly to the questionnaire. 36 (39%) of patients presented anxiety symptoms and 22 (24%) presented depression symptoms. Patients who maintained remission with infliximab (IFX) presented more anxiety symptoms than those who received non-biologic therapies (p = 0.04), probably for having to go to the Hospital every 8 weeks despite being well. Patients with previous bowel resections (p < 0.01) and ileal location (p = 0.02) presented more depressive symptoms. Patients who maintained remission with IFX had a lower risk of presenting depressive symptoms (p = 0.02) than those received non-biologic therapies, probably because those patients previously stayed worse and had experimented a more spectacular improvement. Conclusions: Despite staying in clinical remission, an important number of CD patients present anxiety or depressive symptoms. Patients with a previous bowel resection tend to have more depressive symptoms.