The physicochemical properties of molsidomine preparations and their efficacy in treating IHD and circulatory failure

: Molsidomine drugs corvaton and sidnopharm were assessed clinically, physicochemically and experimentally. Corvaton tablets contained more active substance but less cleavage products than sidnopharm ones. In experiment with acute transitory coronary insufficiency corvaton was active both during myocardial ischemia and in reperfusion. Corvaton showed antianginal effect in 70.3%, sidnopharm in 58.6% of cases. Both drugs produced a positive action on coronary and myocardial reserves in coronary patients with angina class I-III but did not affect hemodynamics. Oral sidnopharm induced side effects 4 times more frequently than corvaton. Corvaton tablets (single dose) activity lasted more than sidnopharm effect by 2.2 hours. Oral corvaton remained active 5.3 hours longer than the same intravenous dose.