Abstract 15465: Effect of Sitagliptin on Left Ventricular Function in Patients With Type 2 Diabetes a Sub Analysis of the PROLOGUE Study

Backgrounds: Effect of dipeptidyl peptidase 4 inhibitor on cardiac function has been issue of debate. We evaluated the effect of sitagliptin on echocardiographic systolic and diastolic parameters as well as N-terminal pro brain natriuretic peptide (NT pro-BNP) in patients with type 2 diabetes as a sub-analysis of the PROLOGUE study. Methods: In the PROLOGUE study, patients were randomly assigned to either add-on sitagliptin treatment (sitagliptin group) or continued conventional antihyperglycemic treatment (conventional group). Among the 463 participants in the PROLOGUE study, echocardiography was performed in 152 patients in the sitagliptin group and 148 patients in the conventional group at the baseline and after 12 and 24 months of treatment. In addition to the routine echocardiographic measurements, mitral annular motion velocity pattern was recorded using pulsed tissue Doppler echocardiography. Early diastolic (e’) peak velocities were measured at mitral annular septal and lateral sides and the ratio...