First trimester maternal characteristics, Doppler parameters and serum analytes after preeclampsia

Objective: To evaluate the impact of prior preeclampsia on first trimester assessment in subsequent pregnancy. Methods: A total of 1283 parous patients were prospectively enrolled at 9–14 weeks of gestation. Maternal biophysical characteristics, ultrasound parameters and placental analytes were compared between women with and without prior preeclampsia. Results: There is no association between prior preeclampsia and the first trimester ultrasound parameters or placental analytes studied. The effects of prior preeclampsia in subsequent pregnancy are exaggerated by increasing parity and are predominantly blood pressure-related, independent of other cardiovascular risk factors. Conclusion: There is a potential role for lifestyle modification and stricter pregnancy blood pressure control in patients with prior preeclampsia.