295-OR: Dyslipidemia and Diabetes in Children and Adolescents with Obesity: A 10-Year Retrospective Study

Introduction: Evidence indicates cardiovascular risk may start early in life. Data on specific risk factors including lipids in childhood and adolescence are scant. We investigate lipid profiles in overweight/obese patients. Methods: Data on pediatric ICLDC patients (N=11,116) with complete lipid profile (2009-2019) were extracted. Overweight/obese category (BMI ≥ 85th percentile) was divided into: prediabetes (Pre-Dia), type1 (T1DM), type 2 (T2DM) and normoglycemic (NGT) groups. Lipid percentiles were calculated for all lipids; distribution curves were plotted on R and statistical analyses performed on SPSS24. Results: Patients (n=4659) included: Pre-Dia (24%), diabetes (T1DM 6%, T2DM 2%) and NGT (68%). Total cholesterol (TC), LDL and non-HDL were significantly increased (p≤0.001) and HDL was significantly decreased (p≤0.001) in diabetes groups compared to NGT; except TC in NGT vs. Pre-Dia. Different trends arose in between diabetes groups whereby TC, LDL and non-HDL were significantly increased (p≤0.001) while HDL was significantly decreased (p≤0.001); except for LDL, non-HDL and TC in T1DM vs. T2DM, non-HDL in Pre-Dia vs. T1DM and TC in Pre-Dia vs. T2DM. Conclusion: Even at an early age, significant increases in TC, LDL and non-HDL, accompanied by decreases in HDL, were observed in patients with type 1, type 2 diabetes and prediabetes groups. Early intervention may need to be considered. Disclosure T. Ali: None. S. Radha: None. R. Helal: None. E. Fojas: None. S. I. El-refer: None. H. M. Sabbour: Speaker’s Bureau; Self; AstraZeneca, Boehringer Ingelheim International GmbH, Novo Nordisk, Novo Nordisk. N. Lessan: None.