LOSS OF CHLORIDE INTRACELLULAR CHANNEL PROTEIN 4 PREVENTS CARDIAC HYPERTROPHY IN ISOPROTERENOL INDUCED PRESSURE OVERLOAD IN MOUSE MODELS

Chloride Intracellular Channel Proteins (CLICs) have been implicated in cardiovascular diseases such as pulmonary arterial hypertension and abnormal angiogenesis. However, no studies have explored the direct role of expression of CLICs on cardiac function or the effect of CLIC-dysregulation in