Assessment of Nitric Oxide and Oxidized LDL associated with low grade inflammation; A Non-Invasive Risk Predictor of Coronary Heart Disease

Coronary Heart Disease arises when cholesterol carried in blood form plaque in the covering of coronary arteries lead to atherosclerosis. The diminished nitric oxide production and inflammation involved in the development of atherosclerosis. The pathogenesis of atherosclerosis are implicated by decreased availability of nitric oxide. Reduced NO level in the endothelium makes it vulnerable and increase the passage of leukocyte and LDL oxidation in the sub endothelial space which ultimately lead to coronary heart disease. Our objective of the study is to evaluate the association of NO and ox-LDL along with hs-CRP in subjects with coronary heart disease. This cross-sectional study showed that the mean Nitric Oxide levels were decreased significantly in CHD group compared to controls. Significant increase in Oxidized LDL and hs-CRP showed in CHD group when compared to controls. Increased oxidative stress associated with diminished bioavailability of nitric oxide undergo oxidative modification of LDL lead to low grade inflammation