Bisoprolol and Hypertension: Effects on Sexual Functioning in Men

Abstract Objectives: To investigate prospectively the effects of the selective β1, adrenoceptor blocker bisoprolol on sexuality of men with hypertension. Design: In newly diagnosed patients (group I): double-blind, crossover, placebo controlled. In men with hypertension on antihypertensive treatment (group II): crossover design. Setting: Large area in and around Rotterdam, The Netherlands. Patients: Twenty-six men (criteria: between 25 and 70; no disease etc. known to affect sexual functioning) were recruited through their general practitioners. Group I (n = 13) fulfilled the selection criteria, sitting blood pressure systolic ≥ 160 mm Hg and/or diastolic ≥ 95 mm Hg, measured on 3 different days. Group II (n = 13) patients already on antihypertensive treatment. Main Outcome Measures: Data on blood pressure. Qualitative and quantitative data on sexuality through questionnaires, including personal and sexual history, sexual functioning, sexual satisfaction and erectile difficulties. Results: Bisoprolol is a...