Long-term results of 11,021 patients with chronic coronary syndrome and after coronarography (from the PRESAGE Registry).

INTRODUCTION There is a paucity of real-world registries concerning patients with chronic coronary syndromes (CCS). OBJECTIVES Assessment of long-term results of patients with CCS and after coronarography performed in accordance with the treatment strategy. PATIENTS AND METHODS The analysis involved 11,021 single-center patients treated between 2006-2016, and enrolled into the ongoing PRESAGE Registry. Based on coronarography outcomes and treatment strategy, patients were classified into 4 groups: non-significant lesions (n=3,637 patients), percutaneous coronary intervention (PCI; n=4,678 patients), coronary artery bypass graft surgery (CABG; n=997 patients), and conservative treatment (notwithstanding significant lesions in the angiogram, n=1,709 patients). The primary outcome measure was death defined as death from any cause, assessed in every group during a 1-, 3-, and 5-year follow-up period. RESULTS The mean age of study patients was 64.6 (9.5) years, and 35.0% of them were women. Patients treated conservatively were the oldest (64.9 [9.3] years) with the highest prevalence of previous myocardial infarction (50.5%), CABG (31.8%), diabetes mellitus (40.3%), chronic total occlusion (65.5%), and the percentage of left ventricular ejection fraction <35% (24.4%). The death from any cause in the non-significant lesions, PCI, CABG, and conservative treatment groups 5 years after index hospitalization occurred in 11.2%, 16.2%, 9.7%, and 21.0% patients, respectively. CONCLUSIONS The PRESAGE registry offers valuable information about clinical characteristics and long-term results of patients with CCS. The population of CCS patients and their distant prognosis is differential with the poorest characteristics and outcomes in those with significant lesions and disqualified from revascularization procedures.