Acute renal insufficiency in poststreptococcal glomerulonephritis and its significance in evaluation of disease development in adults

: Importance of ARF occurring in the acute phase of PSGN in the disease evolution is still disputable because reported results are varying and even contradictory. Examination included 44 patients between 18 and 22 with the acute phase of PSGN. The serum creatinine levels over 124 mmol/l were found in 17 patients, while 27 of them were without ARF in the acute phase of the disease. The aim of the study was, after diagnosing APSGN, to form groups of patients according to the ARF presence and to examine its influence in the initial phase of PSGN on its evolution and prognosis. On the basis of clinical parameters, pH changes, renal rebiopsy and ARF associated with the type of evolution, severity of clinical presentation and pH changes it was shown that occurrence of ARF in the acute phase of PSGN was of no significant importance for clinical presentation of the disease, but it could have some influence on the degree of morphologic changes found by renal rebiopsy.