Abstract 13332: Ventricular Arrhythmias in Patients With Continuous-flow Left Ventricular Assist Devices

Introduction: Ventricular arrhythmias (VAs) pose a significant burden in patients with continuous flow left ventricular assist devices (cfLVADs). However, the incidence, risk factors, and impact on survival are not yet well-described. Hypothesis: We hypothesized that there were demographic, hemodynamic, and comorbid condition parameters that would predict post-VAD arrhythmias and mortality. Methods: We performed a retrospective analysis of 106 consecutive patients undergoing placement of cfLVADs between April 2007 and September 2012. Exploring the outcomes of early VA (occurring during the index hospitalization), late VA (occurring after discharge) and death, we compared demographic, comorbid, pharmacologic, and clinical data. Time to event analyses were undertaken to identify predictors of the outcomes. Results: Most subjects were men (73%) with non-ischemic heart failure (70%) and an ICD (92%) in place. Forty six (43%) patients died. Pre-LVAD VA (hazard ratio [HR] 5.99, p=0.048), chronic kidney disease (HR 2.09, p=0.025) and diabetes (HR 3.61, p Conclusions: Ventricular arrhythmias following LVAD placement are common and predicted by pre-LVAD arrhythmia and ICD therapy, comorbid conditions and medication use. For the rare patient without an ICD placed pre-LVAD, post-operative implantation should be considered.