GROWTH DIFFERENTIATION FACTOR 15 AS A NOVEL BIOMARKER OF HEART FAILURE AND PULMONARY HYPERTENSION IN CONGENITAL HEART DISEASE WITH LEFT TO RIGHT SHUNT IN YOUNG PATIENTS

Growth differentiation factor 15 (GDF 15) is a member of transforming growth factor-beta superfamily. Recent studies suggested that GDF 15 is an early diagnostic marker of heart failure (HF) in repaired congenital heart disease (CHD) and independent biochemical marker of the risk of death in HF.