Out-of-Proportion Pulmonary Hypertension and Heart Failure with Preserved Ejection Fraction

Background: A subset of patients with heart failure with preserved ejection fraction (HFpEF) will have a marked increase in pulmonary artery pressure (PAP). Objective: To evaluate the clinical and hemodynamic characteristics of these patients in comparison to patients with idiopathic pulmonary arterial hypertension (IPAH). Methods: We reviewed the clinical and hemodynamic data of patients with HFpEF with outof-proportion pulmonary hypertension (HFpEF-PH) and compared it to the corresponding data of age-matched patients with IPAH. Results: Twenty consecutive patients with HFpEF-PH and 20 patients with IPAH were included in the study. The mean age ( 8 SD) was 71.3 8 7.8 and 70.2 8 6.7 years, respectively. The majority of the HFpEF-PH patients were postmenopausal females with at least two features