Clinical implications of a prostate cancer risk SNP profile in two treatment cohorts.

e16000 Background: Prostate cancer (PCa) has a heritable risk and genome-wide association studies (GWAS) have so far identified 76 single nucleotide polymorphisms (SNPs) associated with PCa risk. Currently these SNPs have only been evaluated against overall PCa risk and several disease parameters. Their clinical utility remains undefined. We explore the potential prognostic role of the risk SNP profile in 2 PCa cohorts; Active Surveillance (AS) and androgen deprivation therapy (ADT). Methods: PCa patients at the Royal Marsden Hospital who consented for DNA analyses were eligible. 2 separate cohorts were identified; those undergoing AS and those receiving ADT. The risk SNPs were genotyped using Sequenom or Fluidigm platforms. The cumulative SNP risk scores for each patient were calculated by summing risk alleles for each loci using the weighted effect as estimated in previous studies (log-additive model). For the AS group, the risk scores were analysed against defined adverse outcomes in AS, including adve...