Biomedical applications of PLGA particles

Abstract Poly lactic-co-glycolic acid (PLGA) is an established biodegradable polymer. PLGA is the most attractive polymer for the fabrication of drug delivery and tissue engineering applications. Among the different polymers, PLGA has attracted considerable attention to formulate polymeric micro/nanoparticles, due to its attractive properties such as biodegradability, biocompatibility, sustained release, and protection of drug from degradation. Recent research on PLGA has contributed to well-established formulations and methods of production adapted to various types of drugs. The physical and mechanical properties of PLGA can be tuned to provide better interaction with biological materials and to target nanoparticles to specific organs or cells. Overall, PLGA has been broadly studied for the development of controlled delivery drugs. However, the possible toxicity from dose dumping, inconsistent release, and drug–polymer interactions still require detailed evaluation.