Multiple neurological abnormalities, including pontine hemorrhage, multiple sclerosis and aseptic meningitis, during anti-TNF-α therapy in psoriatic arthritis.

Psoriatic arthritis (PsA) is an inflammatory arthritis that affects 5-30% of patients with cutaneous psoriasis [1]. Since tumor necrosis factor (TNF)-α plays critical roles in the development of erosive joint damage, TNF-α inhibitors are an effective treatment for PsA [2]. TNF-α inhibitors are generally considered to be safe with rare severe side effects, but have been reported to cause various immune-mediated diseases, including demyelinating diseases [3]. Recently, we experienced a case of PsA [...]