Study on the correlation between serum adiponectin level and glucolipid metabolism in pregnant women with gestational diabetes mellitus

Objective: To understand the relationship between serum adiponectin(APN) level and glucolipid metabolism in pregnant women with gestational diabetes mellitus(GDM),explore whether APN participates in the formation of glucolipid metabolic disorders among the pregnant women with GDM.Methods: Enzyme-linked immunosorbent assay(ELISA) was used to detect the fasting serum APN levels in 30 pregnant women with GDM and 30 pregnant women with normal glucose tolerance(NGT);the levels of fasting serum total cholesterol(TCH),triglyceride(TG),very low-density lipoprotein cholesterol(VLDL-C),fasting plasma glucose(FPG),and glycosylated hemoglobin A1c(HbA1c) in the two groups were also measured at the same time.Results: ①The fasting serum APN level in GDM group was significantly lower than that in NGT group(P 0.05).②The levels of fasting serum TCH,TG,and VLDL-C in GDM group were significantly higher than those in NGT group(P 0.05).③The levels of FPG and HbA1c in GDM group were significantly higher than those in NGT group(P 0.01).④The results of correlation analysis showed that in the two groups,there was negative correlation between serum APN levels and BMI during the third trimester of pregnancy,FPG,HbA1c,TCH,TG,and VLDL-C(P 0.01 or P 0.05),but there was no correlation between serum APN levels and BMI before pregnancy in the two groups(P 0.05).Conclusion: The serum APN levels in pregnant women with GDM decrease significantly,which may participate in the induction of formation of glucolipid metabolic disorders among the pregnant women with GDM.