Association between coronary heart disease and methylenetetrahydrofolate reductase polymorphism

Objective To explore the correlation between the pathogenesis of coronary heart disease and the polymorphism of methylenetetrahydrofolate reductase (MTHFR). Methods 130 cases of coronary heart disease diagnosed and treated in Heze Municiple Hospital from July 2015 to July 2017 were selected as observation group.At the same time, 130 healthy people were selected as control group.The serum folate and homocysteine(HCY) levels were compared between the two groups.At the same time, polymerase chain reaction-restriction fragment length polymorphism was used to analyze the MTHFR gene polymorphisms.The distribution of MTHFR gene polymorphism was compared between the two groups. Results The level of serum folic acid in the observation group was (5.76±2.14)g/L, which was significantly lower than (7.34±2.43)g/L in the control group (t=5.64, P 0.05), but the serum HCY level of TT type was significantly higher than that of CT type and CC type in the observation group(t=5.33, 4.62, all P<0.05). Conclusion Serum folic acid level, HCY level and homozygous mutations of MTHFR gene type have certain relationship with the occurrence of coronary heart disease, the body serum folic acid level and the distribution of MTHFR genotypes can affect the concentration of HCY, thus affecting the occurrence of coronary heart disease. Key words: Coronary artery disease; Methylenetetrahydrofolate reductase (NADPH2); Folic acid; Homocysteine