Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors

Taku Harada,Eiichiro Yamamoto,Hiro-o Yamano,Hironori Aoki,Hiro-o Matsushita,Kenjiro Yoshikawa,Ryo Takagi,Eiji Harada,Yoshihito Tanaka,Yuko Yoshida,Makoto Eizuka,Akira Yorozu,Gota Sudo,Hiroshi Kitajima,Takeshi Niinuma,Masahiro Kai,Yasushi Sasaki,Takashi Tokino,Tamotsu Sugai,Hiroshi Nakase,Hiromu Suzuki

Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors

2018

Background Recent studies revealed that colorectal tumors are composed of genetically diverse subclones. We aimed to clarify whether the surface microstructures of colorectal tumors are associated with genetic intratumoral heterogeneity (ITH).

Keywords:

General surgery
Diabetes mellitus
Colorectal Tumors
Cancer research
Medicine
Pyrosequencing
pit pattern
Surgical oncology
KRAS
Biopsy
Gene
Mutation

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