Exercise energy expenditure in patients with idiopathic pulmonary arterial hypertension: Impact on clinical severity and survival
2019
Abstract Patient with idiopathic pulmonary hypertension (IPAH) develop peripheral inefficiency which could lead to an increase total energy expenditure and that could have a significant prognostic impact. To test the hypothesis, fifty-five consecutive stable IPAH patients (mean age 51±17 years) and 24 matched controls underwent an incremental exercise test and followed for a 5 years’ period. Total energy expenditure was assessed as the ratio between total V O 2 uptake (during both effort and recovery) and total external work ( V O 2 T O T / W T O T ). Patients with IPAH had a lower exercise capacity and a significantly higher V O 2 T O T / W T O T than controls ( V O 2 T O T / W T O T 0.33 ± 0.09 ml/j vs 0.22 ± 0.04 ml/j, p V O 2 T O T / W T O T was higher in whom died during follow up compared to survivors (0.41 ± 0.11 ml/j vs 0.30 ± 0.06 ml/j, p In multivariate Cox regression analysis V O 2 T O T / W T O T , gender, P ET CO 2 peak , V ˙ O 2 p e a k were independent risk factors for death. Patients with IPAH have shown a less efficient muscular oxygen utilization than controls. Notably the high energy expenditure has a relevant independent prognostic impact.
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