Effects of a rare sugar, D-allulose, coingested with fat on postprandialglycemia and lipidemia in young women.

Aim: Postprandial hyperlipidemia is a major risk factor for coronary heart disease. Our previous study revealed that ingesting fructose with fat cream delays and exacerbates postprandial lipidemia. A rare sugar, D-allulose, has recently attracted attention as an alternative zero-calorie sweetener to natural sugars. In this study, we investigated the effect of ingesting D-allulose with fat cream on postprandial glycemia and lipidemia in young women. Methods: Eleven young Japanese women with apolipoprotein E3/3 phenotype were enrolled. They underwent 4 test trials: fat cream (0.35 g/kg as fat; F trial), fat cream with D-allulose (0.5 g/kg; FA trial), fat cream with fructose (0.5 g/kg; FFr trial), or fat cream with sucrose (0.5 g/kg; FS trial). Blood samples were taken before (0) and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: In the FA trial, serum glucose and fructose concentrations at 0.5 and1 h were significantly lower than those in the FFr and FS trials. In the FA trial, the serum glucose concentration did not increase during the experiment. Serum triglyceride and remnant-like particle-triglyceride concentrations peaked at 2 h in the F trial, and at 4 h in the FA, FFr, and FS trials. Conclusion: When ingested with fat, D-allulose showed almost no glycemic response in contrast to fructose or sucrose. However, ingesting D-allulose with fat may delay postprandial lipidemia similar to these sugars.