ROLE OF SERUM LIPIDS IN GALLSTONE PATHOGENESIS: A CASE–CONTROL STUDY FROM PUNJAB

Objective: Pathogenesis of gallstone (GS) disease is multifactorial, involving both genetic and environmental factors. The main pathogenic factor responsible for the hypersecretion of cholesterol into bile is the impaired lipid metabolism, which actually reflects the likelihood of GS formation. The study aims to determine the significance of serum lipids in the etiology of GS disease and to identify the possible confounding effects of age, gender, and body mass index (BMI) on GS disease. Methods: A case–control study was conducted on 97 ultrasonically confirmed GS cases and 92 healthy controls which were further divided on the basis of gender, age group (≥40 and 0.05). Conclusion: Abnormal lipid parameters, especially high TC and LDL-C, were found to be significantly associated with GS disease. Increased age, obesity, and female gender along with dyslipidemia altogether elevate the risk of formation of GS. The formation of single/multiple stones was not influenced by the abnormal lipid profile, age, gender, and BMI.