Augmented Th17 Differentiation Leads to Cutaneous and Synovio‐Entheseal Inflammation in a Novel Model of Psoriatic Arthritis

Lu Yang,Melania H. Fanok,Aranzazu Mediero‐Munoz,Laura K. Fogli,Carmen Corciulo,Shahla Abdollahi,Bruce N. Cronstein,Jose U. Scher,Sergei B. Koralov

Augmented Th17 Differentiation Leads to Cutaneous and Synovio‐Entheseal Inflammation in a Novel Model of Psoriatic Arthritis

2018

Lu Yang
Melania H. Fanok
Aranzazu Mediero‐Munoz
Laura K. Fogli
Carmen Corciulo
Shahla Abdollahi
Bruce N. Cronstein
Jose U. Scher
Sergei B. Koralov

Objective To introduce a novel pre-clinical animal model of psoriatic arthritis, R26STAT3Cstopfl/fl CD4Cre mice, and investigate the role of Th17 cytokines in the disease pathogenesis.

Keywords:

Immunology
Inflammation
Psoriatic arthritis
Medicine
Enthesitis
Pathogenesis
Stromal cell
Osteoclast
RANKL
Bone marrow

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