Dysregulation of GAS5 and OIP5-AS1 lncRNAs in periodontitis

Abstract Periodontitis as a multifactorial disorder has been associated with dysregulation of several genes which contribute in regulation of immune responses. Recently, a number of studies have addressed the role of long non-coding RNAs (lncRNAs) in the pathogenesis of this disorder. In the current study, we evaluated expression of two lncRNAs, namely GAS5 and OIP5-AS1 in peripheral blood and tissues samples of patients with periodontitis and healthy subjects using quantitative real time PCR. Expression of GAS5 was significantly lower in blood samples obtained from patients with periodontitis compared with normal controls (Posterior beta of RE = −2.677, P value