Patients with Bardet-Biedl Syndrome Have Hyperleptinemia Suggestive of Leptin Resistance

Penelope Feuillan,David Ng,Joan C. Han,Julie C. Sapp,Katie Wetsch,Emma Spaulding,Yuqian C. Zheng,Rafael C. Caruso,Brian P. Brooks,Jennifer J. Johnston,Jack A. Yanovski,Leslie G. Biesecker

Patients with Bardet-Biedl Syndrome Have Hyperleptinemia Suggestive of Leptin Resistance

2011

Penelope Feuillan
David Ng
Joan C. Han
Julie C. Sapp
Katie Wetsch
Emma Spaulding
Yuqian C. Zheng
Rafael C. Caruso
Brian P. Brooks
Jennifer J. Johnston
Jack A. Yanovski
Leslie G. Biesecker

Hyperleptinemia out of proportion to adiposity is found in Bardet-Biedl syndrome, consistent with the leptin resistance shown in mouse models of this ciliopathy.

Keywords:

Ciliopathy
Obesity
Insulin
Insulin resistance
Body mass index
Bardet–Biedl syndrome
Leptin
Endocrinology
Internal medicine
Diabetes mellitus
Medicine

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