Abstract 18026: Pro-angiogenic Dual Gene Therapy in Chronic Diabetic Hindlimb Ischemia with Ultrasound Mediated Delivery of miR-126 and VEGF Plasmid DNA

Wei J Cao,Pratiek N. Matkar,Hao H. Chen,Yu J. Kim,D. Rudenko,Michael A. Kuliszewski,Howard Leong-Poi

Abstract 18026: Pro-angiogenic Dual Gene Therapy in Chronic Diabetic Hindlimb Ischemia with Ultrasound Mediated Delivery of miR-126 and VEGF Plasmid DNA

2014

Wei J Cao
Pratiek N. Matkar
Hao H. Chen
Yu J. Kim
D. Rudenko
Michael A. Kuliszewski
Howard Leong-Poi

Background: MicroRNA (miR)-126 is an endothelial cell specific microRNA that regulates angiogenesis by blocking Sprouty-related protein (SPRED1) and phosphoinositol-3 kinase (PI3K) two endogenous i...

Keywords:

Cardiology
Genetic enhancement
Medicine
Endothelial stem cell
Internal medicine
Kinase
Hindlimb
Angiogenesis
Endogeny
microRNA
PI3K/AKT/mTOR pathway
Cancer research
Diabetes mellitus

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