Original Article Synthesis and preclinical evaluation of a new C-6 alkylated pyrimidine derivative as a PET imaging agent for HSV1-tk gene expression

Ursina Müller,Tobias Ludwig Ross,Charlene Ranadheera,Roger Slavik,Adrienne Müller,Mariana Born,Evelyn Trauffer,Selena Milicevic Sephton,Leonardo Scapozza,Stefanie D. Krämer,Simon M. Ametamey

Original Article Synthesis and preclinical evaluation of a new C-6 alkylated pyrimidine derivative as a PET imaging agent for HSV1-tk gene expression

2013

Ursina Müller
Tobias Ludwig Ross
Charlene Ranadheera
Roger Slavik
Adrienne Müller
Mariana Born
Evelyn Trauffer
Selena Milicevic Sephton
Leonardo Scapozza
Stefanie D. Krämer
Simon M. Ametamey

2University of Geneva, School of Pharmaceutical Sciences, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland Received September 27, 2012; Accepted November 2, 2012; Epub January 5, 2013; Published January 15, 2013

Keywords:

Gene expression
Pyrimidine
Medicinal chemistry
Pharmaceutical sciences
Imaging agent
Toxicology
Medicine
Nanotechnology
Cancer research
pet imaging

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