Clinical Observation of Huatan Lishi Houxue Formula for 96 Patients with Non-Alcoholic Steatohepatitis

Objective To observe the effect of Huatan Lishi Huoxue Formula(formula to transform phlegm,disinhibit dampness and quicken the blood) on alanine aminotransferase(ALT) and the ratio of the liver and the spleen CT values in patients with non-alcoholic steatohepatitis(NASH).Methods Totally 202 NASH patients from 4 centers were randomized into treatment group of 96 cases and the control group of 98 cases.The treatment group was given modified Huatan Lishi Huoxue Formula,one dosage daily.The control group was given polyene phosphatidylcholine(Essentiale) capsule,456mg each time,three times daily.The treatment course lasted for 3 months.The levels of ALT and the ratios of the liver and the spleen CT values were observed pretreatment and on the 90th and 180th day of the treatment.Results The levels of ALT were significantly decreased and the ratios of the liver and the spleen CT values were significantly increased in both groups after 90 and 180 days of treatment(P0.05),especially in the treatment group(P0.05).Conclusion Huatan Lishi Huoxue Formula is effective for NASH.It could significantly decrease the level of ALT and increase the ratio of the liver and the spleen CT values.