Suppression of Plasma Androgen Levels with a Combination Therapy of Depot-Estrogen (TuristeronR) and DexamethasoneR in Patients with Prostatic Cancer

Treatment of patients with prostatic cancer with a combination of 1-2 mg depot-estrogen (ethynylestradiol sulfonate=Turisteron R ) per week and 1 mg dexamethasone per day suppressed the mean testosterone (T) level to 2.8% (0.53 nmol/l), the free T to 0.8% (1.9 pmol/l) and the adrenal androgens (AA) ― androstenedione (A), dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) ― to more than 40% of the initial values. Treatment with Turisteron alone (2 mg per week) did not change the DHEA and DHEAS levels but decreased plasma A concentration to 65% (2.96 nmol/l) of the initial values