Outcome analysis of vitamin-D supplementation in patients with fibromyalgia

Objective: To investigate the vitamin D level and score the pain of fibromyalgia (FM) using VAS scoring at pre- planned intervals. Materials and Methods: 50 patients presenting with FM, treated with vitamin D supplementations were prospectively followed for average duration of 6 months and correlation was also calculated between vitamin D and VAS score.Result: There were 60% female and 40% male and the average age of the patients with FM was 45.066±17.7 female and 43.30.±18.1 male. The mean pain VAS score decreased at intervals (day 1, 3 months and 6 month) in both age and gender group. A significant reduction in pain intensity was observed after each months of vitamin D therapy with p < 0.001. Low Vitamin D level was significantly correlated with VAS on Day 1 and 03 months intervals (r=0.23 p=0.876, r=0.18 p=0.903, r=0.268 p=0.59 and r=0.172 p=0.234, r=0.267 p=0.61, r=0.413, p=0.003) but negative correlated was found on high Vitamin D level after 06 month with VAS score (r=-0.058 p=0.691 and r=-0.070 p=0.630 in respectively). Conclusion: In conclusion, our study confirmed low vitamin D level was significantly correlated with VAS score on Day 1 and 03 months intervals and then negative correlation was found on high vitamin D level after 06 month with VAS. Furthermore, vitamin D was closely related with pain and disease severity.