Severe debilitating polyarticular gout and terminal renal failure in an allopurinol non-responder

Due to the availability of effective uricostatic (allopurinol), uricosuric (benzbromarone) and uricolytic (urate-oxidase) agents chronic polyarticular and tophaceous gout has become a very rare disease. The subject of this report came to our attention in 1993 and 1996 with severe debilitating gout and terminal renal failure despite continuous treatment with allopurinol for more than 20 years. Therefore he seemed to be an allopurinol nonresponder.