AB1070 DIVERSITY ANALYSIS OF INTESTINAL FLORA IN PATIENTS WITH BEHCET’S DISEASE

Background: Behcet’s disease (BD) may be regarded as a polygenic autoinflammatory disease although adaptive immune system has also been implicated in pathogenesis. The specific components of the microbiota with BD that affect the host response leading to disease remain unknown. Regulation of intestinal microbiota would be able to provide new strategy and target for the treatment of BD. Objectives: To study the diversity and the intestinal flora of intestinal microbes in patients with BD and further provide new ideas for clinical treatment. Methods: The stool specimens of 13 BD patients were analyzed at the level of the Phylum, family and genus, and compared with that of 50 healthy controls(HC). Results: Compared with controls, the abundance of intestinal microbiota in patients with BD was significantly different.At the level of phylum, the abundance of Firmicutes was significantly reduced in BD patients compared with that of HC(P Conclusion: The diversity and balance of bacterial community in intestinal microecological environment of patients with BD are significantly different from the healthy control. Intestinal microbiota disorder may be related to the pathogenesis of BD, which might provide theoretical foundation for the regulation of intestinal flora for disease intervention. Disclosure of Interests: None declared