Recovery of pancreatic β-cell function in hemochromatosis : Combined treatment with recombinant human erythropoietin and phlebotomy

Abstract A patient with diabetes mellitus caused by secondary hemochromatosis was treated using recombinant human erythropoietin and phlebotomy. A total of 12 g of iron had been infused in the patient because of iron deficiency anemia. Blood glucose level was 17.3 mmol/L, and hemoglobin AXc level was 9.0% at admission. He was treated using phlebotomy (400 mL per week), along with subcutaneous injection of 3,000 U of recombinant human erythropoietin three times a week. After approximately 100 days, a total of 5,500 mL of blood (2.75 g iron) could be removed. Serum ferritin level decreased from 10,000 μ/L to 4,807 μg/L. Fasting and maximum serum C-peptide immunoreactivity values during 100-g oral glucose tolerance tests were improved from 0.14 nmol/L to 0.42 nmoI/L and from 1.84 nmol/L to 2.61 nmol/L, respectively. This case suggests that pancreatic β-cell recovers in diabetes caused by hemochromatosis by reducing iron overload during a short period.