Ovulation induction and ovarian tumours: the debate continues.

OBJECTIVE: To critically review the published literature regarding the proposed association of ovarian stimulation and increased risk of ovarian tumors. DESIGN: A medline search (1966-1997) was done to identify case reports and epidemiological studies relevant to the issue in question. Review articles and critical reappraisals in the form of comments on studies done were also used. RESULTS: Various case reports, studies and review articles were identified as most relevant. CONCLUSION: Despite a few studies showing an apparent association between ovulation induction and ovarian cancer, support for their results has not been forthcoming. From the available data a causal relationship is not substantiated. To settle this issue large prospective studies are needed. Meanwhile, close clinical surveillance of patients being treated with ovulation induction is required.