Augmentation of IL-6 production contributes to development of gestational diabetes mellitus: An Indian study

Abstract Aim Inflammatory mediators like interleukin-6 (IL-6) and acute phase protein like C-reactive protein (CRP) are supposed to contribute to development of GDM, however clinical data supporting this hypothesis is limited. This study was designed to analyze the association of IL-6 and CRP with development of GDM in Indian females. Methods This case control study included pregnant women diagnosed as GDM (n = 53) and those having normal glucose tolerance (n = 50). Serum levels of IL-6 and CRP were analysed and correlated with various clinical parameters. Results Serum IL-6 levels were significantly high ( p Conclusion High IL-6 levels in gestational diabetes may indicate a possible role for inflammation in pathophysiology of GDM.