Study on anatomical and functional medical image registration methods

Abstract The purpose of this paper is to give an overview of various well known medical image registration techniques with a special focus on registration between anatomical and functional medical images. Examples of anatomical medical images (AMI) are Computer Tomography (CT), Magnetic Resonance Images (MRI), X-ray radiographs and ultrasound etc. whereas Positron Emission Tomography (PET), Single Photon Emission Tomography (SPECT) and fMRI are examples of functional medical images (FMI). Irrespective of such types (AMI or FMI), every case can be considered as a medical imaging modality. All these modalities are widely used by clinicians to study the structure/functionality of human body parts for diagnosis and treatment. It is frequently required to combine PET/SPECT with CT/MRI to simultaneous study the metabolic and molecular information received through PET/SPECT with fine anatomical details observed by CT/MRI. This concurrent study will help in the diagnosis and localization of many diseases like cancer, blockage in coronary arteries and brain-related diseases like Parkinson, Alzheimer etc. Further, in many cases, clinicians are required to co-register one or more anatomical images with functional images, for example, ultrasound-guided biopsy fused with PET and MRI. This registration can be done either at the hardware level or at the software level. The introduction of integrated PET-CT machine increases the acceptability of hardware-based registration systems as compared to software-based methods among the medics. One possible reason for this is the lack of validation of results achieved through software-based registration methods. On the other hand, software-based registration methods also have many advantages over the hardware-based registration systems like lesser exposure to radiation and no need for new investment on hardware etc. In this paper, both the methods with their merits and demerits are discussed in detail.