Clinical efficacy of laparoscopic and open surgery in treatment of gastrointestinal stromal tumor

Objective To explore the clinical efficacy and immune function effect of laparoscop-ic and open surgery in treatment of gastrointestinal stromal tumor. Methods A total of ninety cases of gastrointestinal stromal tumor treated in our hospital from May 2011 to May 2014 were randomly divided into laparoscopic group and control group, with 45 cases in each group. The control group was treated with traditional open operation, while laparoscopic group underwent laparoscopic surgery, and general condi-tions and postoperative complications were compared between two groups after treatment. The two groups were followed up for 6 months, and the levels of T lymphocyte CD3+, CD4+, CD8+, CD4+/CD8+ were detected by flow cytometry. Results Compared with the control group, the amount of bleeding, postoperative ex-haust time, recovery time, eating time, hospitalization time in laparoscopic group were significantly short-ened; the difference between the two groups was statistically significant (P<0.05). The main postoperation complications were gastric paralysis, wound fat liquefaction, incision infection, intestinal obstruction, wound healing, while incidence of intestinal obstruction and wound healing of the laparoscopic group was significantly lower than those of control group (P<0.05). There was statistical difference between the two groups in incidence of postoperative recurrence and metastasis (P<0.05). One month after operation, CD3+, CD4+, CD4+/CD8+ levels were gradually decreased, while CD8+ level gradually increased, followed by CD3+,CD4+, CD4+/CD8+. And CD3+, CD4+, CD4+/CD8+ levels in laparoscopic group were significantly higher than control group at the same period after surgery, the CD8+ level was significantly lower than that of the con-trol group (P<0.05). Conclusion Laparoscopic surgery is better than the traditional open surgery in the treatment of GIST for smaller influence on the immune function and better prognosis. Key words: Gastrointestinal neoplasms; Laparoscopy; Open operation; Gastrointestinal stromal tumor; Complication; Immune function