P-117 Sleeve gastrectomy with enteral bypass (SGEBP): A surgical technique for the treatment of type 2 diabetes in patients with BMI <35 KG/M2

creased at 10 days and 1 month after GBP (Fig.1). Maximal post prandial insulin and GLP-1 levels reached, respectively, 16.3 1.7 mUI/L and 71,7 16.5 pmol/L at baseline, 111.5 38.9* mUI/L and 320.8 84.0* pmol/L at 10 days, and 96.6 10.4* mUI/L and 297.3 79.1* pmol/L at 1 month (*p 0.05 vs. baseline). Conversely, insulin and GLP-1 responses to intravenous glucose were not significantly modified after GBP. Conclusion: Like in obese patients, GBP induced a dramatic increase of postprandial insulin and GLP-1 responses in lean minipigs. Our results support the use of GBP for treating diabetes in patients with a BMI under 35 kg/m. Further studies in this relevant preclinical model could help to decipherate the underlying metabolic effects of GBP