Plasma leptin level is positively associated with blood pressure measures independent of gender and BMI

ABSTRACTBackground: Since the introduction of leptin, many studies suggest an important role for this hormone in obesity–related hypertension. However, in non-obese patients, there are controversial results regarding the possible role of leptin in essential hypertension especially in both sexes and different groups of body mass index (BMI). We aimed to evaluate the association of leptin and hypertension in both female and male gender.Materials and Methods: This cross-sectional study was conducted, recruiting 80 essential hypertensive patients and 80 healthy normotensive volunteers using convenience sampling method. Subjects without history of diabetes mellitus, hyperlipidemia, smoking, thyroid disease and insulin or corticosteroid use were included in two groups of normotensive and hypertensive subjects who were matched for age, sex and BMI. Systolic and diastolic blood pressure (SBP and DBP), weight and height were measured for all subjects and a blood sample was obtained for measurement of leptin, fasti...