Comparison of Level of Pentraxin-3 in Gingival Crevicular Fluid with Chronic Periodontitis in Well Controlled and Uncontrolled Diabetes Mellitus Patients

Background and Aim: Periodontal diseases are characterized by a complex set of biologic interaction between a microbial ecosystem and the host's immune and inflammatory machinery, such interaction play a role in the development of periodontal disease via the release of inflammatory mediators. The usefulness of such inflammatory mediators as biomarkers for Chronic periodontitis in Diabetes Mellitus patients is unknown. In this study, we tested whether gingival crevicular fluid concentration of human Pentraxin – 3; a local inflammatory marker, would be a useful biomarker for detecting Chronic Periodontitis. Methods: 45 patients with chronic periodontitis were divided into 3 groups based on presence / absence of Diabetes mellitus and whether it is well controlled or not. Clinical parameters were recorded. The clinical and radiographic examinations, group allocations, and sampling site selection for all patients were performed. The samples were collected on the subsequent day using microcapillary pipettes. Collected samples were assayed using Enzymes linked immuonosorbent assay. Results: Statistical analysis was done using One Way Anova test, to compare between 3 groups. Independent sample t-test was done for 2 groups comparison. Statistically significant results were found between group A and group C for Russell's periodontal index. Statistically significant results were not found for Pentraxin-3 levels between groups. Conclusion: By this study we can conclude that Pentraxin – 3 in gingival crevicular fluid increases with increase in inflammation irrespective of the presence or absence of the systemic diseases.